(Biology), Duke University, 2001Дў015-2017 Associate Professor, Integrative Structural and Computational Biology (ISCB), Scripps Research 2013-2015 Assistant Professor, Integrative Structural and Computational Biology (ISCB), Scripps Research 2010-2012 Assistant Professor, Molecular Biology, Scripps Research 2008-2010 Research Associate with Dr. Using single particle electron microscopy and electron tomography we are able to visualize these complexes and whole viruses, providing information about the mechanism of inhibition and aiding in the design of better immunogens for eliciting a broadly neutralizing antibody response in humans. We are trying to better understand how these antibodies bind to and neutralize viruses. Recently, broadly neutralizing antibodies targeting these surface spikes have been shown to provide protection against viruses such as HIV and influenza. Membrane proteins expressed on the surface of enveloped viruses mediate viral entry into the cell by recognizing cell surface receptors and initiating endocytosis or membrane fusion. Thus, my group is interested in studying novel membrane proteins using x-ray crystallography, electron microscopy, and other biophysical techniques.

The molecular details underlying the function of most transporters are still unknown. Membrane protein transporters mediate the passage of a wide variety of molecules into and out of the cell. Investigating membrane proteins and viruses using integrative structural biology techniques

Kyle krumrie photoshop 2013-2014